Oh, I like that last part! I wonder if Kyuubi would feel lest bloodthirsty without all the testosterone and other male hormones roaming around Naruto's body? Maybe enough that she could actually teach him some tricks, talk to him in his head, or any of the other things Kyuubi does in 'Friendly Kyuubi' fics. We know from Yamato's past that Orochimaru has knowlege of DNA, so I'm sure Tsunade does as well. So I can very well see her using a medical jutsu to trick Naruto's body into turning all Y-chromosomes into X-chromosomes!
Perhaps the Kyuubi would be like Inner Sakura and become Naruto's cheerleader.







